Sugiyama K, Suzuki Y, Furuta H
Life Sci. 1985 Aug 5;37(5):475-80. doi: 10.1016/0024-3205(85)90410-2.
Peptides responsible for releasing histamine were purified from human parotid saliva. The amino acid composition of the peptides showed a high proportion of histidine, lysine and arginine. Molecular weights of these peptides were between 3000 and 5000 as determined by SDS-acrylamide gel electrophoresis. These peptides induced histamine release from rat-isolated mast cells accompanied with degranulation in a dose-dependent manner over the concentration range 5-50 micrograms/ml.
从人腮腺唾液中纯化出负责释放组胺的肽。这些肽的氨基酸组成显示组氨酸、赖氨酸和精氨酸的比例很高。通过SDS-聚丙烯酰胺凝胶电泳测定，这些肽的分子量在3000至5000之间。在5-50微克/毫升的浓度范围内，这些肽以剂量依赖的方式诱导大鼠分离的肥大细胞释放组胺并伴有脱颗粒现象。
