包含能够释放组胺的人免疫球蛋白E重链序列的合成肽。
Synthetic peptides comprising sequences of the human immunoglobulin E heavy chain capable of releasing histamine.
作者信息
Stanworth D R, Kings M, Roy P D, Moran J M, Moran D M
出版信息
Biochem J. 1979 Jun 15;180(3):665-8. doi: 10.1042/bj1800665.
Abstract
On the basis of previous studies on the structure-activity relationship of model polypeptide histamine liberators, a site within the Fc region of immunoglobulin E antibody molecules has been proposed as that responsible for the direct triggering of target mast cells after antigen challenge. Peptides comprising this region of the epsilon-chain have now been synthesized and shown to induce histamine release from normal rat peritoneal mast cells in a selective manner essentially similar to that mediated by anaphylactic antibody-antigen interaction.
摘要
基于先前对模型多肽组胺释放剂构效关系的研究，有人提出免疫球蛋白E抗体分子Fc区域内的一个位点是抗原攻击后直接触发靶肥大细胞的原因。现已合成了包含ε链该区域的肽，并显示其能以一种与过敏抗体 - 抗原相互作用介导的方式基本相似的选择性方式诱导正常大鼠腹膜肥大细胞释放组胺。
相似文献
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Synthetic peptides comprising sequences of the human immunoglobulin E heavy chain capable of releasing histamine.包含能够释放组胺的人免疫球蛋白E重链序列的合成肽。
Biochem J. 1979 Jun 15;180(3):665-8. doi: 10.1042/bj1800665.
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引用本文的文献
1
2
Immunoglobulin E decapeptide-induced 5-hydroxytryptamine release from rat peritoneal mast cells. Comparison with corticotropin-(1-24)-peptide, polyarginine, polylysine and antigen.免疫球蛋白E十肽诱导大鼠腹腔肥大细胞释放5-羟色胺。与促肾上腺皮质激素-（1-24）-肽、聚精氨酸、聚赖氨酸及抗原的比较。
Biochem J. 1981 Sep 15;198(3):615-9. doi: 10.1042/bj1980615.
3
The capacity of basic peptides to trigger exocytosis from mast cells correlates with their capacity to immobilize band 3 proteins in erythrocyte membranes.碱性肽触发肥大细胞胞吐作用的能力与其固定红细胞膜中带3蛋白的能力相关。
Biochem J. 1984 Oct 1;223(1):67-71. doi: 10.1042/bj2230067.
4
The effects of substance P on histamine and 5-hydroxytryptamine release in the rat.P物质对大鼠体内组胺和5-羟色胺释放的影响。
J Physiol. 1982 Sep;330:393-411. doi: 10.1113/jphysiol.1982.sp014347.
5
Further studies on histamine release from rat mast cells in vitro induced by peptides. Characteristics of a synthetic intermediate with potent releasing activity.关于肽类诱导大鼠肥大细胞体外组胺释放的进一步研究。具有强释放活性的合成中间体的特性。
Biochem J. 1980 Oct 1;191(1):233-7. doi: 10.1042/bj1910233.
6
A comparison of the histamine-releasing properties of rat pleural and peritoneal mast cells.大鼠胸膜和腹膜肥大细胞组胺释放特性的比较。
Immunology. 1980 Oct;41(2):271-8.
7
Further studies on the structural requirements for polypeptide-mediated histamine release from rat mast cells.关于多肽介导大鼠肥大细胞释放组胺的结构要求的进一步研究。
Biochem J. 1979 Sep 1;181(3):623-32. doi: 10.1042/bj1810623.
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