Fjellner B, Arnetz B B, Eneroth P, Kallner A
Acta Derm Venereol. 1985;65(3):199-205.
The influence of experimentally-induced emotional stress on pruritic response of human skin was studied in healthy subjects. Experimental activation of the psychoneuroendocrine system was produced by standardized stressors, i.e. a colour-word-conflict test (Stroop-test) and a subsequent mental arithmetic problem. Pruritus was elicited by intradermal injection of histamine. Results obtained were compared with reported feelings of stress, and stress-induced physiological and biochemical changes. Reported stress levels were evaluated by a visual analogue scale. The physiological and biochemical observations included pulse rate, blood pressure, endocrine and metabolic parameters. The experimental model produced adequate psychoneuroendocrine stress reactions. Cutaneous responses to histamine remained despite this unaltered. The cutaneous responses were unrelated to reported stress levels as well as to physiological and biochemical variables prior to stressor exposure. The individual cutaneous reactions to stressor exposure were related to the adrenaline response pattern. Degree of control, ability to predict, and time limitation of the experimental situation may be important factors influencing the experimental outcome.
在健康受试者中研究了实验性诱导的情绪应激对人体皮肤瘙痒反应的影响。通过标准化应激源，即颜色-单词冲突测试（斯特鲁普测试）和随后的心算问题，激活心理神经内分泌系统。通过皮内注射组胺引发瘙痒。将获得的结果与报告的应激感受以及应激诱导的生理和生化变化进行比较。通过视觉模拟量表评估报告的应激水平。生理和生化观察包括脉搏率、血压、内分泌和代谢参数。该实验模型产生了足够的心理神经内分泌应激反应。尽管如此，对组胺的皮肤反应仍未改变。皮肤反应与报告的应激水平以及应激源暴露前的生理和生化变量无关。个体对应激源暴露的皮肤反应与肾上腺素反应模式有关。实验情况的控制程度、预测能力和时间限制可能是影响实验结果的重要因素。
