INSERM, U872, LRMA, Equipe 12 du Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie, UMR S 872, Paris, France; Université Paris Descartes, UMR S 872, Paris, France; Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Clin Microbiol Infect. 2014 May;20(5):O297-300. doi: 10.1111/1469-0691.12405. Epub 2013 Nov 11.
The in vitro activity of cefoxitin and imipenem was compared for 43 strains of the Mycobacterium abscessus complex, mostly isolated from cystic fibrosis patients. The MICs of imipenem were lower than those of cefoxitin, although the number of imipenem-resistant strains was higher according to the CLSI breakpoints. Strain comparisons indicated that the MICs of cefoxitin were significantly higher for Mycobacterium bolletii than for M. abscessus. The MICs of both β-lactams were higher for the rough morphotype than for the smooth morphotype. The clinical impact of the in vitro difference between the activity of imipenem and that of cefoxitin remains to be determined.
我们比较了头孢西丁和亚胺培南对 43 株脓肿分枝杆菌复合群的体外活性，这些菌株主要分离自囊性纤维化患者。虽然根据 CLSI 折点，耐亚胺培南菌株的数量更高，但亚胺培南的 MIC 值低于头孢西丁。菌株比较表明，头孢西丁的 MIC 值对于博莱氏分枝杆菌明显高于脓肿分枝杆菌。两种β-内酰胺类药物的 MIC 值对于粗糙型比光滑型更高。亚胺培南和头孢西丁体外活性差异的临床影响仍有待确定。
