离子通道的结构波动与电流噪声
Structural fluctuations and current noise of ionic channels.
作者信息
Läuger P
出版信息
Biophys J. 1985 Sep;48(3):369-73. doi: 10.1016/S0006-3495(85)83793-0.
Abstract
In the open state of the acetylcholine-receptor channel an increased current noise is observed, which may result from conformational fluctuations of the channel protein (Sigworth, F.J., 1985, Biophys. J. 47:709-720). In this study the spectrum of the current noise is analyzed assuming that low-frequency motions of structural domains of the protein give rise to conductance fluctuations. The movement of a domain is treated as the motion of an elastically bound Brownian particle, which is described by the Langevin equation. The current-noise spectrum predicted by this model is given by a sum of Lorentzians; it agrees with the observed spectrum when it is assumed that only the slowest process can be resolved in the experiment. The large value of the friction coefficient, which is obtained from the corner frequency, indicates that domain motion is restricted mainly by peptide-peptide interactions.
摘要
在乙酰胆碱受体通道的开放状态下，观察到电流噪声增加，这可能是由于通道蛋白的构象波动所致（西格沃思，F.J.，1985年，《生物物理学杂志》47:709 - 720）。在本研究中，假设蛋白质结构域的低频运动引起电导波动，对电流噪声的频谱进行了分析。一个结构域的运动被视为一个弹性束缚的布朗粒子的运动，由朗之万方程描述。该模型预测的电流噪声频谱由洛伦兹函数之和给出；当假设在实验中只能分辨出最慢的过程时，它与观察到的频谱相符。从转折频率获得的摩擦系数的较大值表明，结构域运动主要受肽 - 肽相互作用的限制。
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1
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J Mol Biol. 1981 Feb 5;145(4):825-33. doi: 10.1016/0022-2836(81)90317-x.
2
Time dependence of atomic fluctuations in proteins: analysis of local and collective motions in bovine pancreatic trypsin inhibitor.蛋白质中原子涨落的时间依赖性：牛胰蛋白酶抑制剂中局部和集体运动的分析
Biochemistry. 1982 Oct 12;21(21):5230-41. doi: 10.1021/bi00264a019.
3
Structure and function of an acetylcholine receptor.乙酰胆碱受体的结构与功能。
Biophys J. 1982 Jan;37(1):371-83. doi: 10.1016/S0006-3495(82)84685-7.
4
The fluidity of cell membranes and its regulation.细胞膜的流动性及其调控
Prog Biophys Mol Biol. 1981;38(1):1-104. doi: 10.1016/0079-6107(81)90011-0.
5
The internal dynamics of globular proteins.球状蛋白质的内部动力学。
CRC Crit Rev Biochem. 1981;9(4):293-349. doi: 10.3109/10409238109105437.
6
Characterization of the distribution of internal motions in the basic pancreatic trypsin inhibitor using a large number of internal NMR probes.使用大量内部核磁共振探针表征碱性胰蛋白酶抑制剂内部运动的分布情况。
Q Rev Biophys. 1983 Feb;16(1):1-57. doi: 10.1017/s0033583500004911.
7
Harmonic dynamics of proteins: normal modes and fluctuations in bovine pancreatic trypsin inhibitor.蛋白质的谐波动力学：牛胰蛋白酶抑制剂的正常模式与波动
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6571-5. doi: 10.1073/pnas.80.21.6571.
8
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