三碘甲状腺原氨酸可刺激在无血清培养基中培养的胎儿下丘脑细胞产生胰岛素样生长因子（IGF）。
Triiodothyronine stimulates the production of insulin-like growth factor (IGF) by fetal hypothalamus cells cultured in serum-free medium.
作者信息
Binoux M, Faivre-Bauman A, Lassarre C, Barret A, Tixier-Vidal A
出版信息
Brain Res. 1985 Aug;353(2):319-21. doi: 10.1016/0165-3806(85)90222-6.
Grown in serum-free medium, dissociated cells from fetal mouse hypothalami release insulin-like growth factors (IGFs) and their binding proteins (IGF BPs) into the culture medium. Addition of triiodothyronine (10-12-10-8 M), which enhances neuron maturation, resulted in a significant increase in IGF concentration. By contrast, there was no significant effect on IGF BP. These results suggest a role for thyroid hormone in the control of IGF biosynthesis in nerve cells.
在无血清培养基中培养时，来自胎鼠下丘脑的解离细胞会将胰岛素样生长因子（IGFs）及其结合蛋白（IGF BPs）释放到培养基中。添加能促进神经元成熟的三碘甲状腺原氨酸（10^-12 - 10^-8 M）后，IGF浓度显著增加。相比之下，对IGF BP没有显著影响。这些结果表明甲状腺激素在神经细胞中IGF生物合成的控制中发挥作用。
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