Kunishige Hideyuki, Ishibashi Yoshimitsu, Kawasaki Masakazu, Morimoto Kiyotaka, Inoue Nozomu
The Division of Cardiovascular Surgery, National Hospital Organization Hokkaido Medical Center, Sapporo, Hokkaido, Japan.
Ann Vasc Dis. 2013;6(3):631-6. doi: 10.3400/avd.cr.13-00035. Epub 2013 Sep 5.
The purpose of this study is to identify the risk factors affecting the high mortality rates associated with the treatment of ruptured abdominal aortic aneurysm (AAA).
In this retrospective study, the subjects consisted of 105 patients who underwent repair of ruptured AAA at our institution from December 1984 to March 2012. We compared the patients of ruptured AAA in survival group with those in death group to evaluate the clinical factors in ruptured AAA mortality.
The operative and in-hospital mortality of ruptured AAA patients was 22.9% compared with 1.9% for that of non-ruptured AAA patients. The mean hemoglobin level was significantly lower in death group than in survival group. Intraoperative bleeding volume was significantly higher in death group than in survival group. Cox proportional hazard analysis showed that level 3 or 4 according to the Rutherford classification, preoperative hemoglobin level of less than 9.0 g/dl, intraoperative blood loss volume of more than 3000 ml, postoperative bowel ischemia and class 3 or 4 according to the Fitzgerald classification were significantly associated with high mortality.
These findings showed that every effort to maintain preoperative hemodynamic stability reduce volumes of blood loss in operation, and to minimize postoperative deterioration of organ functions would be essential to improve patient survival.
本研究旨在确定影响腹主动脉瘤(AAA)破裂治疗相关高死亡率的危险因素。
在这项回顾性研究中,研究对象包括1984年12月至2012年3月在我院接受破裂性AAA修复手术的105例患者。我们比较了破裂性AAA存活组和死亡组患者,以评估影响破裂性AAA死亡率的临床因素。
破裂性AAA患者的手术死亡率和住院死亡率为22.9%,而非破裂性AAA患者为1.9%。死亡组的平均血红蛋白水平显著低于存活组。死亡组的术中出血量显著高于存活组。Cox比例风险分析显示,根据卢瑟福分类法为3级或4级、术前血红蛋白水平低于9.0 g/dl、术中失血量超过3000 ml、术后肠缺血以及根据菲茨杰拉德分类法为3级或4级与高死亡率显著相关。
这些发现表明,为提高患者生存率,尽一切努力维持术前血流动力学稳定、减少手术失血量以及尽量减少术后器官功能恶化至关重要。