Iwarson S, Schaff Z, Seto B, Norkrans G, Gerety R J
J Med Virol. 1985 May;16(1):37-45. doi: 10.1002/jmv.1890160106.
Retrovirus-like particles 60-85 nm in diameter were observed in the cytoplasm of hepatocytes in liver biopsies obtained during the acute and chronic phases of non-A, non-B hepatitis (NANBH) in three patients with transfusion-acquired disease. The particles appeared in dilated endoplasmic reticulum cisternae as well as in enlarged Golgi vesicles. No such particles were seen in hepatocytes in liver biopsies similarly obtained during the acute or chronic phases of NANBH from 11 additional patients with NANBH who did not acquire their disease following blood transfusion. Particle-associated reverse transcriptase activity (peak activity at a density of 1.14 gm/ml) was present in the sera of all three "particle-positive" patients and also in 42% of the "particle-negative" patients. The retrovirus-like particles described here were apparently unrelated to the previously described human T cell lymphocytotropic retroviruses (HTLV), since none of the 14 patients studied had antibodies in their serum directed against antigens of any of the three known HTLVs.
在三名输血后感染非甲非乙型肝炎（NANBH）的患者急性和慢性期肝活检标本的肝细胞胞质中观察到直径为60 - 85纳米的逆转录病毒样颗粒。这些颗粒出现在扩张的内质网池以及增大的高尔基体小泡中。在另外11名非输血后感染NANBH的患者急性或慢性期类似获取的肝活检标本的肝细胞中未见到此类颗粒。所有三名“颗粒阳性”患者的血清中均存在颗粒相关的逆转录酶活性（密度为1.14克/毫升时活性峰值），42%的“颗粒阴性”患者血清中也有该活性。这里描述的逆转录病毒样颗粒显然与先前描述的人类嗜T细胞逆转录病毒（HTLV）无关，因为所研究的14名患者血清中均无针对三种已知HTLV任何一种抗原的抗体。
