Seto B, Coleman W G, Iwarson S, Gerety R J
Lancet. 1984 Oct 27;2(8409):941-3. doi: 10.1016/s0140-6736(84)91163-2.
Particle-associated reverse transcriptase activity was detected in four human serum specimens and in two plasma-derived products, all of which had been shown to transmit non-A, non-B hepatitis (NANBH) to other human beings and/or chimpanzees. Reverse transcriptase activity was also detected in all twelve sera from patients with acute or chronic NANBH. In contrast, reverse transcriptase activity was found in only 2 of 49 serum specimens from healthy plasma donors and laboratory workers. Sucrose density gradient fractions of two of the infectious human sera (peak reverse transcriptase activity at 1.14 g/ml) transmitted NANBH to chimpanzees. Biochemical and enzymatic data indicate that the NANBH agent(s) is a retrovirus or is retrovirus-like.
在4份人类血清标本和2份血浆衍生制品中检测到了与颗粒相关的逆转录酶活性，所有这些标本和制品均已被证明能将非甲非乙型肝炎（NANBH）传播给其他人类和/或黑猩猩。在急性或慢性NANBH患者的所有12份血清中也检测到了逆转录酶活性。相比之下，在49份来自健康血浆捐献者和实验室工作人员的血清标本中，仅在2份中发现了逆转录酶活性。两份具有传染性的人类血清的蔗糖密度梯度级分（在1.14 g/ml处逆转录酶活性峰值）将NANBH传播给了黑猩猩。生化和酶学数据表明，NANBH病原体是一种逆转录病毒或类似逆转录病毒。
