肿瘤荷瘤小鼠中纳米颗粒聚集和解离动力学的近红外荧光能量转移成像。
Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice.
机构信息
Condensed Matter and Interfaces, Debye Institute for Nanomaterials Science, Utrecht University , Princetonplein 5, 3584 CC Utrecht, The Netherlands.
出版信息
ACS Nano. 2013 Nov 26;7(11):10362-70. doi: 10.1021/nn404782p. Epub 2013 Oct 24.
Abstract
In the current study we show the dissociation and tumor accumulation dynamics of dual-labeled near-infrared quantum dot core self-assembled lipidic nanoparticles (SALNPs) in a mouse model upon intravenous administration. Using advanced in vivo fluorescence energy transfer imaging techniques, we observed swift exchange with plasma protein components in the blood and progressive SALNP dissociation and subsequent trafficking of individual SALNP components following tumor accumulation. Our results suggest that upon intravenous administration SALNPs quickly transform, which may affect their functionality. The presented technology provides a modular in vivo tool to visualize SALNP behavior in real time and may contribute to improving the therapeutic outcome or molecular imaging signature of SALNPs.
摘要
在当前的研究中，我们展示了在静脉注射后，双标记近红外量子点核自组装脂质纳米粒子（SALNP）在小鼠模型中的解离和肿瘤积累动力学。我们使用先进的体内荧光能量转移成像技术，观察到血液中与血浆蛋白成分的快速交换以及 SALNP 解离的逐渐进展，以及随后的单个 SALNP 成分在肿瘤积累后的转运。我们的结果表明，静脉注射后，SALNP 会迅速发生转化，这可能会影响它们的功能。所提出的技术提供了一种模块化的体内工具，可以实时可视化 SALNP 的行为，并可能有助于改善 SALNP 的治疗效果或分子成像特征。
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