Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
J Med Virol. 2014 May;86(5):899-904. doi: 10.1002/jmv.23786. Epub 2013 Oct 17.
Influenza-like-illness can be caused by a wide range of respiratory viruses. The etiology of influenza-like-illness in developing countries such as Papua New Guinea is poorly understood. The etiological agents associated with influenza-like-illness were investigated retrospectively for 300 nasopharyngeal swabs received by the Papua New Guinea National Influenza Centre in 2010. Real-time PCR/RT-PCR methods were used for the detection of 13 respiratory viruses. Patients with influenza-like-illness were identified according to the World Health Organization case definition: sudden onset of fever (>38°C), with cough and/or sore throat, in the absence of other diagnoses. At least one viral respiratory pathogen was detected in 66.3% of the samples tested. Rhinoviruses (17.0%), influenza A (16.7%), and influenza B (12.7%) were the pathogens detected most frequently. Children <5 years of age presented with a significantly higher rate of at least one viral pathogen and a significantly higher rate of co-infections with multiple viruses, when compared to all other patients >5 years of age. Influenza B, adenovirus, and respiratory syncytial virus were all detected at significantly higher rates in children <5 years of age. This study confirmed that multiple respiratory viruses are circulating and contributing to the presentation of influenza-like-illness in Papua New Guinea.
流感样疾病可由多种呼吸道病毒引起。在巴布亚新几内亚等发展中国家，流感样疾病的病因尚不清楚。本研究回顾性调查了 2010 年巴布亚新几内亚国家流感中心收到的 300 份鼻咽拭子，以了解与流感样疾病相关的病因。采用实时 PCR/RT-PCR 方法检测了 13 种呼吸道病毒。根据世界卫生组织的病例定义，将流感样疾病患者定义为：突然发热（>38°C），伴有咳嗽和/或喉咙痛，无其他诊断。在检测的样本中，至少有一种病毒呼吸道病原体的检出率为 66.3%。鼻病毒（17.0%）、甲型流感（16.7%）和乙型流感（12.7%）是最常检测到的病原体。与所有其他年龄>5 岁的患者相比，<5 岁的儿童至少有一种病毒病原体的检出率显著更高，且合并多种病毒感染的检出率也显著更高。在<5 岁的儿童中，乙型流感、腺病毒和呼吸道合胞病毒的检出率均显著更高。本研究证实，多种呼吸道病毒在巴布亚新几内亚流行，并导致流感样疾病的发生。
