Service Viral Diseases, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, 1050, Brussels, Belgium.
Eur J Clin Microbiol Infect Dis. 2012 Jun;31(6):999-1007. doi: 10.1007/s10096-011-1398-4. Epub 2011 Sep 8.
The purpose of this investigation was to determine the proportion of influenza-like illness (ILI) attributable to specific viruses during the influenza A(H1N1)2009 pandemic and to describe the demographic and clinical characteristics of ILI due to respiratory viruses in Belgium. Nasopharyngeal swabs were collected from ILI patients by general practitioners (GPs) and paediatricians (PediSurv) and analysed for viruses. Of 139 samples collected from children <5 years of age by PediSurv, 86 were positive, including 28 influenza (20%), 27 respiratory syncytial virus (RSV) (19%), 21 rhinovirus (17%), 12 human metapneumovirus (hMPV) (9%) and ten parainfluenza virus (PIV) (7%). Of 810 samples received from GPs, 426 were influenza (53%). Of 312 influenza-negative samples, 41 were rhinovirus (13%), 13 RSV (4%), 11 PIV (4%) and three hMPV (1%). Influenza mostly affected the 6-15 years old age group. Other respiratory viruses were commonly detected in the youngest patients. Similar clinical symptoms were associated with different respiratory viruses. Influenza A(H1N1)2009 was the most detected virus in ILI patients during the 2009-2010 winter, suggesting a good correlation between ILI case definition and influenza diagnosis. However, in children under 5 years of age, other respiratory viruses such as RSV were frequently diagnosed. Furthermore, our findings do not suggest that the early occurrence of the influenza A(H1N1)2009 epidemic impacted the RSV epidemic in Belgium.
本研究旨在确定在甲型 H1N1 流感大流行期间流感样疾病（ILI）归因于特定病毒的比例，并描述比利时因呼吸道病毒引起的 ILI 的人口统计学和临床特征。家庭医生（GPs）和儿科医生（PediSurv）从 ILI 患者中采集鼻咽拭子并进行病毒分析。在 PediSurv 从 5 岁以下儿童采集的 139 份样本中，86 份为阳性，包括 28 份流感（20%）、27 份呼吸道合胞病毒（RSV）（19%）、21 份鼻病毒（17%）、12 份人偏肺病毒（hMPV）（9%）和 10 份副流感病毒（PIV）（7%）。从 GPs 收到的 810 份样本中，426 份为流感（53%）。在 312 份流感阴性样本中，41 份为鼻病毒（13%）、13 份 RSV（4%）、11 份 PIV（4%）和 3 份 hMPV（1%）。流感主要影响 6-15 岁年龄组。其他呼吸道病毒在年龄最小的患者中经常被检测到。不同的呼吸道病毒与相似的临床症状相关。在 2009-2010 年冬季，甲型 H1N1 流感是 ILI 患者中检测到的最常见病毒，这表明 ILI 病例定义与流感诊断之间存在良好的相关性。然而，在 5 岁以下儿童中，经常诊断出其他呼吸道病毒，如 RSV。此外，我们的研究结果表明，甲型 H1N1 流感大流行的早期发生并没有对比利时 RSV 流行产生影响。
