State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Org Lett. 2013 Nov 1;15(21):5512-5. doi: 10.1021/ol402516p. Epub 2013 Oct 18.
Aphanamenes A (1) and B (2), two unprecedented acyclic diterpene dimers formed via a [4 + 2]-cycloaddition, were isolated from the root bark of Aphanamixis grandifolia. Their structures were elucidated by spectroscopic analyses, and the absolute configuration of 1 was determined by ECD calculations. Both 1 and 2 showed significant inhibition on NO production on lipopolysaccharide-induced RAW264.7 macrophages.
从大根香叶的根皮中分离得到了两个前所未有的非环二萜二聚体 Aphanamenes A（1）和 B（2），它们是通过 [4 + 2]-环加成反应形成的。通过光谱分析阐明了它们的结构，并通过 ECD 计算确定了 1 的绝对构型。1 和 2 均对脂多糖诱导的 RAW264.7 巨噬细胞中 NO 生成有显著抑制作用。
