State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, PR China.
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Fitoterapia. 2022 Jun;159:105192. doi: 10.1016/j.fitote.2022.105192. Epub 2022 Mar 31.
Fifteen diterpene derivatives including seven new ones, sinensisins A-G (1, 2, 4, 7, 10, 14, 15), were obtained from the leaves and twigs of Aphanamixis sinensis. Their structures were elucidated by NMR spectroscopic and ECD data analyses. These diverse carbon skeletons containing meroditerpenoids, acyclic diterpenes, and norditerpenoids biogenetically were derived from chain-like diterpenes. Compounds 3, 5, and 6 showed inhibitory effects of nitric oxide (NO) production in LPS-induced RAW 264.7 cells.
从阿潘木属植物的叶子和小枝中获得了 15 种二萜类衍生物，包括 7 种新化合物，即 sinensisins A-G（1、2、4、7、10、14、15）。通过 NMR 光谱和 ECD 数据分析阐明了它们的结构。这些含有 meroditerpenoids、acyclic diterpenes 和 norditerpenoids 的不同碳骨架生物起源于链状二萜。化合物 3、5 和 6 对 LPS 诱导的 RAW 264.7 细胞中一氧化氮（NO）产生具有抑制作用。
