来自大叶山楝根皮的抗炎二萜二聚体。

Anti-inflammatory diterpene dimers from the root barks of Aphanamixis grandifolia.

作者信息

Zhang Hong-Jian, Zhang Yang-Mei, Luo Jian-Guang, Luo Jun, Kong Ling-Yi

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

出版信息

Org Biomol Chem. 2015 Jul 21;13(27):7452-8. doi: 10.1039/c5ob00674k.

DOI:10.1039/c5ob00674k

PMID:26062044

Abstract

A total of 14 new diterpene dimers, aphanamenes C-P ()1-14, with four known homologous compounds were isolated from the root barks of Aphanamixis grandifolia Bl. The structures of these compounds were elucidated by spectroscopic analyses, and their absolute configurations were determined using the CD exciton chirality method. In addition, all the compounds exhibited significant inhibition of lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC50 values between 7.75 and 38.23 μM.

摘要

从大花麻楝（Aphanamixis grandifolia Bl.）的根皮中总共分离出14个新的二萜二聚体，即隐木脂素C - P（1 - 14），以及4个已知的同系物。通过光谱分析阐明了这些化合物的结构，并使用圆二色激子手性方法确定了它们的绝对构型。此外，所有化合物在RAW264.7巨噬细胞中均表现出对脂多糖诱导的一氧化氮产生有显著抑制作用，IC50值在7.75至38.23 μM之间。