Division of Pathophysiology and Pharmacology, College of Pharmacy, Chung-Ang University, 84 Heukseok-Ro, Dongjak-Gu, Seoul, 156-756, South Korea,
Inflamm Res. 2014 Jan;63(1):53-60. doi: 10.1007/s00011-013-0670-8. Epub 2013 Oct 20.
Asthma is an inflammatory disease of the lung that is characterized by airway hyperresponsiveness and the increase of inflammatory cell infiltration into the airways. Naturally occurring flavones have potent anti-inflammatory effects, but their effects on asthmatic responses are still relatively unknown.
We evaluated the inhibitory effects of flavone derivatives having the chromone moiety on the immediate-phase asthmatic response (IAR) and the late-phase asthmatic response (LAR) to aerosolized-ovalbumin (OA) exposure in conscious OA-sensitized guinea pigs.
Luteolin and apigenin (30 mg/kg, p.o.) significantly (P < 0.05) decreased not only the specific airway resistance (sRaw) in IAR and LAR, but also the recruitment of leukocytes and the release of histamine and activities of phospholipase A2 (PLA2) and eosinophil peroxide (EPO) in bronchoalveolar lavage fluid (BALF), compared to control. However, their anti-asthmatic activities were less than those of cromolyn sodium and dexamethasone.
These results indicate that flavones containing more hydroxyl radicals have a greater anti-asthmatic effect. The potencies of flavone anti-asthmatic activities are, in order: luteolin ≥ apigenin > baicalein > chrysin > flavone.
哮喘是一种肺部炎症性疾病，其特征为气道高反应性和炎症细胞浸润气道增加。天然存在的类黄酮具有很强的抗炎作用，但它们对哮喘反应的影响仍相对未知。
我们评估了具有色酮部分的类黄酮衍生物对清醒的卵清蛋白（OA）致敏豚鼠雾化 OA 暴露引起的即时相哮喘反应（IAR）和迟相哮喘反应（LAR）的抑制作用。
木樨草素和芹菜素（30mg/kg，po）显著（P<0.05）降低了 IAR 和 LAR 中的气道特异性阻力（sRaw），以及白细胞募集和支气管肺泡灌洗液（BALF）中组胺释放以及磷脂酶 A2（PLA2）和嗜酸性粒细胞过氧化物酶（EPO）的活性，与对照组相比。然而，它们的抗哮喘活性低于克仑特罗酸钠和地塞米松。
这些结果表明，含有更多羟基的类黄酮具有更强的抗哮喘作用。类黄酮抗哮喘活性的效价顺序为：木樨草素≥芹菜素>黄芩素>白杨素>黄酮。
