State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
School of Clinical Medicine, North Sichuan Medical College, Nanchong 637002, China.
Molecules. 2024 Jun 5;29(11):2673. doi: 10.3390/molecules29112673.
Hemorrhoid disease is a common anorectal disorder affecting populations worldwide, with high prevalence, treatment difficulties, and considerable treatment costs. Compared to other treatment options, medical therapy for hemorrhoids offers minimal harm, more dignity to patients, and is more economical. Unfortunately, there are few chemical hemorrhoid medications available clinically, which makes the search for efficacious, cost-effective, and environmentally friendly new medication classes a focal point of research. In this context, searching for available natural products to improve hemorrhoids exhibits tremendous potential. These products are derived from nature, predominantly from plants, with a minor portion coming from animals, fungi, and algae. They have excellent coagulation pathway regulation, anti-inflammatory, antibacterial, and tissue regeneration activities. Therefore, we take the view that they are a class of potential hemorrhoid drugs, prevention products, and medication add-on ingredients. This article first reviews the factors contributing to the development of hemorrhoids, types, primary symptoms, and the mechanisms of natural products for hemorrhoids. Building on this foundation, we screened natural products with potential hemorrhoid improvement activity, including polyphenols and flavonoids, terpenes, polysaccharides, and other types.
痔病是一种常见的肛肠疾病，影响着全球人群，具有高患病率、治疗困难和相当高的治疗费用。与其他治疗选择相比，痔病的医学治疗具有最小的伤害、更高的患者尊严和更经济的优势。然而，临床上可用的化学痔病药物很少，这使得寻找有效、经济实惠且环保的新型药物类别成为研究的重点。在这种情况下，寻找可用的天然产品来改善痔病具有巨大的潜力。这些产品源自大自然，主要来自植物，一小部分来自动物、真菌和藻类。它们具有出色的凝血途径调节、抗炎、抗菌和组织再生活性。因此，我们认为它们是一类有潜力的痔病药物、预防产品和药物添加成分。本文首先回顾了痔病发展的因素、类型、主要症状以及天然产品治疗痔病的机制。在此基础上，我们筛选了具有潜在痔病改善活性的天然产品，包括多酚和类黄酮、萜类化合物、多糖和其他类型。
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