Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Mar-Apr;6(2):155-62. doi: 10.1002/wnan.1250. Epub 2013 Oct 23.
Dendrimers are versatile macromolecules with tremendous potential as magnetic resonance imaging (MRI) contrast agents. Dendrimer-based agents provide distinct advantages over low-molecular-weight gadolinium chelates, including enhanced r1 relaxivity due to slow rotational dynamics, tunable pharmacokinetics that can be adapted for blood pool, liver, kidney, and lymphatic imaging, the ability to be a drug carrier, and flexibility for labeling due to their inherent multivalency. Clinical applications are increasingly being developed, particularly in lymphatic imaging. Herein we present a broad overview of dendrimer-based MRI contrast agents with attention to the unique chemistry and physical properties as well as emerging clinical applications.
树状高分子是一种多功能的大分子，具有作为磁共振成像（MRI）对比剂的巨大潜力。基于树状高分子的试剂相对于低分子量的钆螯合物具有明显的优势，包括由于缓慢的旋转动力学而增强的 r1 弛豫率、可适应血池、肝脏、肾脏和淋巴成像的可调节的药代动力学、作为药物载体的能力以及由于其固有多价性而具有的标记灵活性。临床应用正在越来越多地得到开发，特别是在淋巴成像方面。本文对基于树状高分子的 MRI 对比剂进行了广泛的概述，重点介绍了其独特的化学和物理特性以及新兴的临床应用。
