Université d'Artois, Laboratoire de Physiopathologie de la Barrière Hémato-encéphalique, EA 2465 - IMPRT 114, Faculté Jean Perrin, Rue Jean Souvraz, S.P. 18, F-62300 Lens, France.
Curr Alzheimer Res. 2013 Dec;10(10):1015-33. doi: 10.2174/15672050113106660174.
Ever since amyloid-β (Aβ) peptides were first identified in cerebral plaques in patients with Alzheimer's disease (AD), much research work has focused on the complex mechanisms through which these peptides are synthesized, transported and degraded. Although new information emerges on a regular basis, we consider that the importance of the blood-brain barrier (BBB) in the pathogenesis of AD has been underestimated. In fact, there are a number of obstacles that make it difficult to convince specialists in AD that the BBB indeed plays a key role in this disease: these include the complex physiology of the BBB and the technical difficulty of studying the barrier in vivo and reproducing its main properties in vitro. With these considerations in mind, the present review sets out summarize our current knowledge about the physiology of the BBB and describe recent research findings on the barrier's role in Aβ peptide proteostasis and thus in the mechanism of AD.
自从淀粉样蛋白-β (Aβ) 肽在阿尔茨海默病 (AD) 患者的脑斑块中首次被发现以来，大量研究工作集中在这些肽的合成、运输和降解的复杂机制上。尽管定期出现新的信息，但我们认为血脑屏障 (BBB) 在 AD 发病机制中的重要性被低估了。事实上，有许多障碍使得很难让 AD 专家相信 BBB 确实在这种疾病中起关键作用：这些障碍包括 BBB 的复杂生理学以及在体内研究屏障和在体外复制其主要特性的技术难度。考虑到这些因素，本综述旨在总结我们目前对 BBB 生理学的认识，并描述最近关于屏障在 Aβ 肽蛋白平衡中的作用以及 AD 机制中的作用的研究发现。
