de Juan-Marcos L, Cabrillo-Estévez L, Escudero-Domínguez F A, Sánchez-Jara A, Hernández-Galilea E
Servicio de Oftalmología, Hospital Clínico Universitario de Salamanca, Salamanca, España; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, España.
Arch Soc Esp Oftalmol. 2013 Nov;88(11):439-44. doi: 10.1016/j.oftal.2013.06.010. Epub 2013 Sep 5.
To evaluate the corneal endothelial morphometry and central corneal thickness (CCT) in pseudoexfoliative (PEX) eyes with and without glaucoma and to compare with normal eyes and eyes with primary open-angle glaucoma (POAG).
A total of 166 patients were included in this study: 36 eyes with pseudoexfoliation syndrome (PXS), 30 eyes with pseudoexfoliation glaucoma (PXG), 40 eyes with POAG, and 60 normal eyes. Corneal endothelial cell density (ECD), coefficient of variation (CV) in cell size, and percentage of hexagonal cells, were measured using a non-contact specular microscope, whereas CCT was measured with an ultrasonic pachymeter.
ECD and percentage of hexagonal cells were lower in PEX groups and in the POAG group compared with normal eyes, while the CV in cell size was greater. There was a tendency for greater cell loss and morphological abnormalities of the corneal endothelial cells in PXG eyes compared to PXS eyes, when all pseudoexfoliative eyes were analyzed together. Changes in endothelial cells increased with age. There were no significant differences in mean CCT between the four groups.
Endothelial cell density is significantly decreased, and pleomorphism and polymegathism of cells are increased in PEX eyes, particularly when intraocular pressure is high.
评估有无青光眼的假性剥脱（PEX）眼的角膜内皮形态学和中央角膜厚度（CCT），并与正常眼和原发性开角型青光眼（POAG）眼进行比较。
本研究共纳入166例患者：36只假性剥脱综合征（PXS）眼、30只假性剥脱性青光眼（PXG）眼、40只POAG眼和60只正常眼。使用非接触式角膜内皮显微镜测量角膜内皮细胞密度（ECD）、细胞大小变异系数（CV）和六角形细胞百分比，而使用超声角膜测厚仪测量CCT。
与正常眼相比，PEX组和POAG组的ECD和六角形细胞百分比更低，而细胞大小的CV更大。当将所有假性剥脱性眼一起分析时，与PXS眼相比，PXG眼中角膜内皮细胞的丢失和形态异常有增加的趋势。内皮细胞的变化随年龄增长而增加。四组之间的平均CCT无显著差异。
PEX眼中内皮细胞密度显著降低，细胞的多形性和大小不均一性增加，尤其是在眼压高时。
