Yen Ju-Yu, Tu Hung-Pin, Chen Cheng-Sheng, Yen Cheng-Fang, Long Cheng-Yu, Ko Chih-Hung
Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):729-39. doi: 10.1007/s00406-013-0466-4. Epub 2013 Oct 26.
Estrogen and serotonin play vital roles in the mechanism of premenstrual dysphoric disorder (PMDD). Cognitive deficit in the premenstrual phase contributes to impaired life function among women with PMDD. The aim of this study was to evaluate the difficulties in cognitive control and working memory (WM) in PMDD and to explore the effects of gonadotropic hormone and polymorphism of serotonin 1A receptor (HTR1A; rs6295) on cognitive deficit in PMDD. Women with PMDD completed diagnostic interviewing, questionnaire assessment, the Go/Nogo task, 2-back and 3-back tasks, and gonadotropic hormone analysis in the premenstrual and follicular phases. Further, they were followed up for two menstrual cycles to confirm two consecutive symptomatic cycles. A total of 59 subjects with PMDD and 74 controls completed all evaluation, fulfilled the criteria, and entered into the final analysis. The results demonstrated cognitive control and WM decline in the premenstrual among women with PMDD. The G/G genotype of HTR1A (rs6295) was found to be associated with impaired WM in the premenstrual phase and premenstrual decline of cognitive function. It also contributed to the vulnerability of cognitive function to the menstrual cycle effect and PMDD effect. As the G/G genotype of HTR1A (rs6295) involves in reducing serotonin neurotransmission, our results provide insight into the serotonin mechanism of cognitive function among women with PMDD.
雌激素和血清素在经前烦躁障碍（PMDD）的发病机制中起着至关重要的作用。经前期的认知缺陷会导致PMDD女性的生活功能受损。本研究的目的是评估PMDD患者在认知控制和工作记忆（WM）方面的困难，并探讨促性腺激素和血清素1A受体（HTR1A；rs6295）基因多态性对PMDD认知缺陷的影响。患有PMDD的女性在经前期和卵泡期完成了诊断性访谈、问卷调查、Go/Nogo任务、2-back和3-back任务以及促性腺激素分析。此外，对她们进行了两个月经周期的随访，以确认连续两个有症状的周期。共有59名PMDD患者和74名对照完成了所有评估，符合标准并进入最终分析。结果表明，PMDD女性在经前期的认知控制和WM下降。发现HTR1A（rs6295）的G/G基因型与经前期WM受损和经前期认知功能下降有关。它还导致认知功能易受月经周期效应和PMDD效应的影响。由于HTR1A（rs6295）的G/G基因型参与减少血清素神经传递，我们的结果为PMDD女性认知功能的血清素机制提供了见解。
