Bäärnhielm Maria, Olsson Tomas, Alfredsson Lars
Institute of Environmental Medicine, Karolinska Institutet, Sweden.
Mult Scler. 2014 May;20(6):726-32. doi: 10.1177/1352458513509508. Epub 2013 Oct 24.
High vitamin D levels have been associated with a decreased risk of developing multiple sclerosis (MS). The most important source of dietary vitamin D is fatty fish.
The objective of this paper is to investigate the association between fish consumption and the risk of MS, including the interaction between fish intake and ultraviolet radiation (UVR) exposure habits.
This study is based on the project Epidemiological Investigation of MS (EIMS), which is a Swedish population-based case-control study. The analysis included 1879 incident cases of MS and 4135 controls. Subjects who reported high fatty fish intake were compared regarding occurrence of MS with those who reported low intake by calculating odds ratio (OR) with 95% confidence interval (CI).
Frequent fatty fish intake was associated with decreased occurrence of MS (adjusted OR 0.82 (95% CI 0.68-0.98). There was no significant association between intake of lean fish and MS.
Fatty fish intake might decrease the risk for MS. A hypothetical explanation is that intake of fatty fish may compensate for vitamin D deficiency that is associated with increased MS risk.
高维生素D水平与患多发性硬化症（MS）风险降低有关。膳食中维生素D的最重要来源是富含脂肪的鱼类。
本文旨在研究鱼类消费与MS风险之间的关联，包括鱼类摄入量与紫外线辐射（UVR）暴露习惯之间的相互作用。
本研究基于MS流行病学调查（EIMS）项目，这是一项基于瑞典人群的病例对照研究。分析纳入了1879例新发MS病例和4135例对照。通过计算比值比（OR）及95%置信区间（CI），比较报告高脂肪鱼类摄入量的受试者与报告低摄入量的受试者发生MS的情况。
经常食用高脂肪鱼类与MS发生率降低有关（校正OR 0.82（95%CI 0.68 - 0.98））。食用瘦鱼与MS之间无显著关联。
摄入高脂肪鱼类可能降低患MS的风险。一种假设性解释是，摄入高脂肪鱼类可能弥补与MS风险增加相关的维生素D缺乏。
