Alghamdi Maha Ali, Fallica Antonino N, Virzì Nicola, Kesharwani Prashant, Pittalà Valeria, Greish Khaled
Department of Biotechnology, College of science, Taif University, Taif 21974, Saudi Arabia.
Department of Molecular Medicine, Princess Al-Jawhara Centre for Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Bahrain.
J Pers Med. 2022 Apr 22;12(5):673. doi: 10.3390/jpm12050673.
Both personalized medicine and nanomedicine are new to medical practice. Nanomedicine is an application of the advances of nanotechnology in medicine and is being integrated into diagnostic and therapeutic tools to manage an array of medical conditions. On the other hand, personalized medicine, which is also referred to as precision medicine, is a novel concept that aims to individualize/customize therapeutic management based on the personal attributes of the patient to overcome blanket treatment that is only efficient in a subset of patients, leaving others with either ineffective treatment or treatment that results in significant toxicity. Novel nanomedicines have been employed in the treatment of several diseases, which can be adapted to each patient-specific case according to their genetic profiles. In this review, we discuss both areas and the intersection between the two emerging scientific domains. The review focuses on the current situation in personalized medicine, the advantages that can be offered by nanomedicine to personalized medicine, and the application of nanoconstructs in the diagnosis of genetic variability that can identify the right drug for the right patient. Finally, we touch upon the challenges in both fields towards the translation of nano-personalized medicine.
个性化医疗和纳米医疗对于医学实践来说都是新事物。纳米医疗是纳米技术在医学领域进展的一种应用，正被整合到诊断和治疗工具中以应对一系列医疗状况。另一方面，个性化医疗，也被称为精准医疗，是一个新颖的概念，旨在根据患者的个人特征对治疗管理进行个体化/定制化，以克服仅对一部分患者有效的一刀切式治疗，使其他患者要么接受无效治疗，要么接受会导致严重毒性的治疗。新型纳米药物已被用于多种疾病的治疗，这些药物可以根据每个患者的基因图谱进行调整以适应具体病例。在这篇综述中，我们将讨论这两个领域以及这两个新兴科学领域之间的交叉点。该综述聚焦于个性化医疗的现状、纳米医疗可为个性化医疗带来的优势，以及纳米结构体在诊断基因变异方面的应用，这种诊断能够为合适的患者确定合适的药物。最后，我们探讨了这两个领域在纳米个性化医疗转化方面所面临的挑战。
