基于间日疟原虫裂殖子表面蛋白基因的朝鲜半岛纵向和横断面遗传多样性
Longitudinal and Cross-Sectional Genetic Diversity in the Korean Peninsula Based on the P vivax Merozoite Surface Protein Gene.
作者信息
Kim Jung-Yeon, Suh Eun-Jung, Yu Hyo-Soon, Jung Hyun-Sik, Park In-Ho, Choi Yien-Kyeoug, Choi Kyoung-Mi, Cho Shin-Hyeong, Lee Won-Ja
机构信息
Division of Malaria and Parasitic Diseases, Korea National Institute of Health, Osong, Korea.
出版信息
Osong Public Health Res Perspect. 2011 Dec;2(3):158-63. doi: 10.1016/j.phrp.2011.11.039.
OBJECTIVES
Vivax malaria has reemerged and become endemic in Korea. Our study aimed to analyze by both longitudinal and cross-sectional genetic diversity of this malaria based on the P vivax Merozoite Surface Protein (PvMSP) gene parasites recently found in the Korean peninsula.
METHODS
PvMSP-1 gene sequence analysis from P vivax isolates (n = 835) during the 1996-2010 period were longitudinally analyzed and the isolates from the Korean peninsula through South Korea, the demilitarized zone and North Korea collected in 2008-2010 were enrolled in an overall analysis of MSP-1 gene diversity.
RESULTS
New recombinant subtypes and severe multiple-cloneinfection rates were observed in recent vivax parasites. Regional variation was also observed in the study sites.
CONCLUSION
This study revealed the great complexity of genetic variation and rapid dissemination of genes in P vivax. It also showed interesting patterns of diversity depending, on the region in the Korean Peninsula. Understanding the parasiteninsula. Under genetic variation may help to analyze trends and assess the extent of endemic malaria in Korea.
目的
间日疟在韩国再度出现并成为地方病。我们的研究旨在基于最近在朝鲜半岛发现的间日疟原虫裂殖子表面蛋白（PvMSP）基因寄生虫，通过纵向和横断面分析这种疟疾的遗传多样性。
方法
对1996 - 2010年期间间日疟分离株（n = 835）的PvMSP - 1基因序列进行纵向分析，并将2008 - 2010年从韩国、非军事区和朝鲜收集的朝鲜半岛分离株纳入MSP - 1基因多样性的全面分析。
结果
在近期的间日疟原虫中观察到新的重组亚型和严重的多克隆感染率。在研究地点也观察到区域差异。
结论
本研究揭示了间日疟原虫遗传变异的极大复杂性和基因的快速传播。它还显示了取决于朝鲜半岛地区的有趣的多样性模式。了解寄生虫的遗传变异可能有助于分析趋势并评估韩国地方疟的流行程度。
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