Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea.
Am J Trop Med Hyg. 2010 Mar;82(3):426-32. doi: 10.4269/ajtmh.2010.09-0245.
Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.
韩国虽然持续投入政府力量，但疟原虫再度出现的间日疟仍然未能根除，反而成为地方病。本研究目的在于，分析疟原虫红内期表面蛋白-1（PvMSP-1）与环子孢子蛋白（PvCSP）基因在再出现后的长期遗传多样性，以了解目前的流行状况。1996 年至 2007 年共分析 632 株间日疟原虫的 PvMSP-1 基因序列，最近取得的多数分离株与初期再出现时的分离株不同。最初只有一种重组型，2000 年后出现各种亚型，最近更发现六种 MSP-1 亚型。CSP 基因分析也有类似变化，发现新的 CSP 亚型。了解寄生虫的遗传变异模式，有助于分析韩国疟疾流行趋势和程度。
