韩国间日疟原虫种群结构的动态变化
Dynamic changes of Plasmodium vivax population structure in South Korea.
作者信息
Kang Jung-Mi, Lee Jinyoung, Cho Pyo-Yun, Kim Tae Im, Sohn Woon-Mok, Park Jae-Won, Kim Tong-Soo, Na Byoung-Kuk
机构信息
Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, South Korea; BK21Plus Team for Anti-aging Biotechnology and Industry, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, South Korea.
Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, South Korea.
出版信息
Infect Genet Evol. 2016 Nov;45:90-94. doi: 10.1016/j.meegid.2016.08.023. Epub 2016 Aug 22.
The vivax malaria epidemic has persisted in South Korea since its reemergence in 1993. Although there has been a significant decrease in the number of malaria cases in recent years, vivax malaria is still a major public health concern. To gain in-depth insight into the genetic makeup of Korean Plasmodium vivax, we analyzed polymorphic patterns of two major antigens, merozoite surface protein-1 (MSP-1) and MSP-3α, in 255 Korean P. vivax isolates collected over an extended period from 1998 to 2013. Combinational genetic analysis of polymorphic patterns of MSP-1 and MSP-3α in the isolates suggests that the P. vivax population in South Korea has been diversifying rapidly, with the appearance of parasites with new genotypes, despite the recent reduction of disease incidence. These results highlight the importance of molecular epidemiological investigations to supervise the genetic variation of the parasite in South Korea.
自1993年间日疟再次出现以来，韩国间日疟疫情一直持续。尽管近年来疟疾病例数量显著下降，但间日疟仍是一个主要的公共卫生问题。为深入了解韩国间日疟原虫的基因构成，我们分析了1998年至2013年期间收集的255株韩国间日疟原虫分离株中两种主要抗原——裂殖子表面蛋白-1（MSP-1）和MSP-3α的多态性模式。对这些分离株中MSP-1和MSP-3α多态性模式的联合基因分析表明，尽管近期疾病发病率有所下降，但韩国间日疟原虫种群一直在迅速分化，出现了具有新基因型的寄生虫。这些结果凸显了分子流行病学调查对于监测韩国寄生虫基因变异的重要性。
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