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韩国军人间日疟原虫分离株中pvmdr1单核苷酸多态性及微卫星基因型的评估

Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel.

作者信息

Chung Dong-Il, Jeong Sookwan, Dinzouna-Boutamba Sylvatrie-Danne, Yang Hye-Won, Yeo Sang-Geon, Hong Yeonchul, Goo Youn-Kyoung

机构信息

Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, 101 Dongin-2-ga, Joong-gu, Daegu, 70-422, Republic of Korea.

Department of Medicine, Headquarters of Republic of Korea Army, Choongnam, Republic of Korea.

出版信息

Malar J. 2015 Sep 4;14:336. doi: 10.1186/s12936-015-0845-6.

DOI:10.1186/s12936-015-0845-6
PMID:26337571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4559299/
Abstract

BACKGROUND

Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria.

METHODS

To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax.

RESULTS

Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011.

CONCLUSIONS

Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.

摘要

背景

氯喹已被用于韩国士兵预防间日疟原虫疟疾。近期氯喹耐药寄生虫数量的增加引发了对间日疟原虫疟疾化学预防和治疗的担忧。

方法

为监测韩国氯喹耐药寄生虫的发展情况，对从55名感染间日疟原虫的韩国士兵采集的样本进行了pvmdr1单核苷酸多态性（SNP）分析和微卫星标记分析。

结果

鉴定出四个SNP，即F1076L、T529、E1233和S1358。其中，S1358是首次在韩国检测到。基于微卫星的研究显示，2012年采集的样本中的遗传多样性高于2011年。

结论

综合来看，结果表明带有新鉴定的pvmdr1 SNP的间日疟原虫已传入韩国间日疟原虫种群。因此，为控制韩国的间日疟原虫疟疾，需要持续监测氯喹耐药寄生虫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8937/4559299/c0e04297e86b/12936_2015_845_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8937/4559299/46bfe3995a08/12936_2015_845_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8937/4559299/c0e04297e86b/12936_2015_845_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8937/4559299/46bfe3995a08/12936_2015_845_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8937/4559299/c0e04297e86b/12936_2015_845_Fig2_HTML.jpg

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