Hort J F
Curr Med Res Opin. 1975;3(5):333-7. doi: 10.1185/03007997509114784.
By far the largest proportion of adverse reactions reported with the use of alclofenac relate to skin rashes. Estimates of the incidence of rash in approximately 1,500 patients participating in clinical trials suggest that this reaction occurred principally with the tablet (10.3%) rather than the later capsule formulation (2.1%) and since the tablet form has been discontinued there have been fewer reports. Detailed investigation of medical records and re-examination of patients developing a rash with alclofenac therapy indicate that there may be a "cross-sensitivity" between alclofenac and other drugs such as penicillin, gold salts and salicylates. Other adverse reactions to alclofenac, such as gastro-intestinal haemorrhage and blood disorders, have been reported only rarely.
使用阿氯芬酸报告的不良反应中，到目前为止最大比例与皮疹有关。对参与临床试验的约1500名患者的皮疹发生率估计表明，这种反应主要发生在片剂（10.3%）而非后来的胶囊剂型（2.1%）中，并且自从片剂剂型停产以来，报告的病例减少了。对病历的详细调查以及对接受阿氯芬酸治疗出现皮疹的患者的重新检查表明，阿氯芬酸与其他药物如青霉素、金盐和水杨酸盐之间可能存在“交叉敏感性”。关于阿氯芬酸的其他不良反应，如胃肠道出血和血液系统疾病，仅有极少的报告。
