Bulgen D Y, Hazleman B L
Curr Med Res Opin. 1975;3(5):321-8. doi: 10.1185/03007997509114782.
Eighteen patients with definite ankylosing spondylitis were treated with 3 to 4 g. alclofenac daily for up to 8 months in an open trial against previous therapy. Therapeutic efficacy was greater than or equivalent to previous therapy in 10 of 18 patients after 1 month and 8 patients remain on alclofenac. There was a significant increase in symptoms, particularly morning stiffness after 1 month, but they tended to improve with time. Measurement of spinal movements was not found useful. Side-effects were commoner than expected but not serious. Alclofenac may prove a useful alternative drug in the management of ankylosing spondylitis and further trials are indicated.
在一项开放性试验中，18例确诊的强直性脊柱炎患者接受了每日3至4克阿氯芬酸的治疗，疗程长达8个月，与之前的治疗方法进行对比。1个月后，18例患者中有10例的治疗效果优于或等同于之前的治疗，8例患者继续使用阿氯芬酸治疗。1个月后症状显著加重，尤其是晨僵，但随着时间推移症状趋于改善。未发现测量脊柱活动度有帮助。副作用比预期更常见，但并不严重。阿氯芬酸可能被证明是治疗强直性脊柱炎的一种有用的替代药物，有必要进行进一步试验。
