Armenian Saro H, Chow Eric J
Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, California.
Cancer. 2014 Feb 15;120(4):469-79. doi: 10.1002/cncr.28444. Epub 2013 Oct 25.
Hematopoietic cell transplantation (HCT) is increasingly offered as a curative option for many patients with hematologic malignancies. Improvements in HCT strategies and supportive care have resulted in a growing number of long-term survivors. However, these survivors are at an increased risk of developing long-term debilitating chronic health conditions, including premature cardiovascular disease. These complications are more common than in the general population, and there are well-described associations between therapeutic exposures, traditional cardiovascular risk factors, and subsequent cardiovascular disease risk. The authors present herein an overview of the current state of knowledge regarding pathogenesis and risk factors for some of the more commonly occurring cardiovascular complications after HCT, highlighting existing surveillance recommendations and future directions for research to minimize cardiovascular morbidity in these survivors.
造血细胞移植（HCT）越来越多地被作为许多血液系统恶性肿瘤患者的治愈性选择。HCT策略和支持性护理的改进使得长期存活者的数量不断增加。然而，这些存活者发生长期使人衰弱的慢性健康问题的风险增加，包括过早出现的心血管疾病。这些并发症在普通人群中更为常见，并且在治疗暴露、传统心血管危险因素与随后的心血管疾病风险之间存在着详尽描述的关联。作者在此概述了目前关于HCT后一些较常见心血管并发症的发病机制和危险因素的知识现状，强调了现有的监测建议以及为将这些存活者的心血管发病率降至最低的未来研究方向。
