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在注射λ DNA 过程中脂质体中跨膜通道的形成。

Formation of transmembrane channels in liposomes during injection of lambda DNA.

作者信息

Roessner C A, Ihler G M

出版信息

J Biol Chem. 1986 Jan 5;261(1):386-90.

PMID:2416751
Abstract

Bacteriophage lambda binds to unilamellar liposomes bearing its receptor protein, LamB, and the lambda DNA can be injected into the internal aqueous space. During this process, transmembrane channels are formed in the liposomes which permit the entry and escape of small molecules, but not proteins. The channels are stable and persist after DNA injection.

摘要

噬菌体λ可与携带其受体蛋白LamB的单层脂质体结合,λ DNA能够被注入内部水相空间。在此过程中,脂质体中会形成跨膜通道,这些通道允许小分子进出,但蛋白质无法通过。这些通道很稳定,在DNA注入后依然存在。

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