酒精与免疫学：2012年酒精与免疫学研究兴趣小组（AIRIG）会议总结
Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meeting.
作者信息
Ippolito Jill A, Curtis Brenda J, Choudhry Mashkoor A, Kovacs Elizabeth J
机构信息
Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Campus, Maywood, IL 60153, United States; Integrative Cell Biology Program, Loyola University Chicago Health Sciences Campus, Maywood, IL 60153, United States; Department of Microbiology and Immunology, Loyola University Chicago Health Sciences Campus, Maywood, IL 60153, United States.
出版信息
Alcohol. 2013 Dec;47(8):589-93. doi: 10.1016/j.alcohol.2013.09.003. Epub 2013 Oct 1.
On October 27, 2012, the 17th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the Grand Wailea Hotel in Maui, Hawaii as a satellite meeting to the 2012 Society of Leukocyte Biology conference. This year's meeting focused on the influence of alcohol on signal transduction pathways in various disease and injury models. Three plenary sessions were held where invited speakers shared their research on alcohol-mediated alterations of cell signaling components, immune cell subsets, and inflammation. These studies suggested alcohol has a negative effect on cell signaling machinery and immune cell homeostasis, resulting in disease, disease progression, and increased mortality. Researchers also identified tissue-specific alcohol-linked elevations in markers of inflammation, including cold-shock proteins and microRNAs. Additionally, one study revealed the effects of alcohol on immune cell subsets in a model of allergic asthma.
2012年10月27日，第17届年度酒精与免疫研究兴趣小组（AIRIG）会议在夏威夷毛伊岛的大威雷亚酒店举行，作为2012年白细胞生物学学会会议的卫星会议。今年的会议聚焦于酒精对各种疾病和损伤模型中信号转导通路的影响。会议举行了三场全会，邀请的演讲者分享了他们关于酒精介导的细胞信号成分、免疫细胞亚群和炎症改变的研究。这些研究表明，酒精对细胞信号传导机制和免疫细胞稳态有负面影响，导致疾病、疾病进展和死亡率增加。研究人员还发现了与酒精相关的特定组织炎症标志物升高，包括冷休克蛋白和微小RNA。此外，一项研究揭示了酒精在过敏性哮喘模型中对免疫细胞亚群的影响。
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