Kaida Hayato, Kawahara Akihiko, Hayakawa Masanobu, Hattori Satoshi, Kurata Seiji, Fujimoto Kiminori, Azuma Koichi, Hirose Yasumitsu, Takamori Shinzo, Hiromatsu Yuji, Nakashima Tadashi, Fujita Hiromasa, Kage Masayoshi, Hayabuchi Naofumi, Ishibashi Masatoshi
aDivision of Nuclear Medicine, PET Center, and Department of Radiology, Kurume University School of Medicine bDepartment of Diagnostic Pathology, Kurume University Hospital cBiostatistics Center dDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine eDepartment of Surgery fDivision of Endocrinology, Department of Internal Medicine gDepartment of Otolaryngology and Facial Maxillary Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Nucl Med Commun. 2014 Jan;35(1):36-43. doi: 10.1097/MNM.0000000000000019.
The aim of this study was to reveal the differences in clinicopathological factors affecting maximum standardized uptake value (SUVmax) between esophageal squamous cell carcinoma (ESCC), non-small-cell lung cancer (NSCLC), and papillary thyroid cancer (PTC).
This study consisted of 119 patients with ESCC (n=43), PTC (n=40), or NSCLC (n=36). We investigated the correlations between SUVmax and clinicopathological factors by using Spearman's correlation coefficient and the Kruskal-Wallis test. Multiple regression analysis was used to investigate which clinicopathological factors significantly affected SUVmax in each cancer type.
The SUVmax correlated with glucose transporter-1 (GLUT-1) expression in NSCLC (r=0.536, P=0.007) and ESCC (r=0.597, P<0.001) but not in PTC. The SUVmax correlated with Ki-67 expression in NSCLC (r=0.381, P=0.022) and PTC (r=0.374, P=0.017) but not in ESCC. A high SUVmax was correlated with a higher pathological T stage (p-T stage) in NSCLC (r=0.536) and ESCC (r=0.597, both P<0.001) but not in PTC. An elevated SUVmax was significantly associated with pathological lymph node status (p-N) in NSCLC, but not in ESCC and PTC. In multiple regression analysis, p-T stage and GLUT-1 expression were statistically significant factors in ESCC, and p-T stage was a statistically significant factor in NSCLC. In PTC, Ki-67 showed a statistically significant association with SUVmax.
SUVmax in NSCLC depended on the tumor invasion area; SUVmax in ESCC depended on tumor depth and GLUT-1 expression; and SUVmax in PTC might be associated with cell proliferation. The biological factors affecting SUVmax differ according to tumor type.
本研究旨在揭示影响食管鳞状细胞癌（ESCC）、非小细胞肺癌（NSCLC）和甲状腺乳头状癌（PTC）最大标准化摄取值（SUVmax）的临床病理因素差异。
本研究纳入了119例ESCC患者（n = 43）、PTC患者（n = 40）或NSCLC患者（n = 36）。我们使用Spearman相关系数和Kruskal-Wallis检验研究SUVmax与临床病理因素之间的相关性。采用多元回归分析研究每种癌症类型中哪些临床病理因素对SUVmax有显著影响。
SUVmax与NSCLC（r = 0.536，P = 0.007）和ESCC（r = 0.597，P < 0.001）中的葡萄糖转运蛋白1（GLUT-1）表达相关，但与PTC无关。SUVmax与NSCLC（r = 0.381，P = 0.022）和PTC（r = 0.374，P = 0.017）中的Ki-67表达相关，但与ESCC无关。高SUVmax与NSCLC（r = 0.536）和ESCC（r = 0.597，均P < 0.001）中更高的病理T分期（p-T分期）相关，但与PTC无关。SUVmax升高与NSCLC中的病理淋巴结状态（p-N）显著相关，但与ESCC和PTC无关。在多元回归分析中，p-T分期和GLUT-1表达是ESCC中的统计学显著因素，p-T分期是NSCLC中的统计学显著因素。在PTC中，Ki-67与SUVmax显示出统计学显著关联。
NSCLC中的SUVmax取决于肿瘤浸润区域；ESCC中的SUVmax取决于肿瘤深度和GLUT-1表达；PTC中的SUVmax可能与细胞增殖有关。影响SUVmax的生物学因素因肿瘤类型而异。
