甲状腺乳头状癌患者临床病理因素与氟-18-氟脱氧葡萄糖摄取之间的关系

Relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose uptake in patients with papillary thyroid cancer.

作者信息

Kaida Hayato, Hiromatsu Yuji, Kurata Seiji, Kawahara Akihiko, Hattori Satoshi, Taira Tomoki, Kobayashi Maiko, Uchida Masafumi, Yamada Kentaro, Mihashi Hiroyuki, Umeno Hirohito, Kage Masayoshi, Nakashima Tadashi, Hayabuchi Naofumi, Ishibashi Masatoshi

机构信息

Division of Nuclear Medicine, PET Center, Department of Radiology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan.

出版信息

Nucl Med Commun. 2011 Aug;32(8):690-8. doi: 10.1097/MNM.0b013e32834754f1.

DOI:10.1097/MNM.0b013e32834754f1

PMID:21606885

Abstract

OBJECTIVE

To examine the relationship between clinicopathological factors and fluorine-18-fluorodeoxyglucose (F-FDG) uptake in patients with papillary thyroid cancer (PTC).

MATERIALS AND METHODS

Fifty-four patients were included in this study.F-FDG positron emission tomography was performed before surgery. Immunohistochemistry of glucose transporter (GLUT) was performed using postoperative histopathological specimens. We investigated the relationship between maximum standardized uptake value (SUVmax) and GLUT-1, GLUT-3, and GLUT-4 expression/SUVmax and prognostic risk factors {tumor size, age, sex, extrathyroidal extension, and lymph node metastasis [ly (+)]}.

RESULTS

GLUT-3 and GLUT-4 expressions significantly correlated with SUVmax (GLUT-3: r=0.38, P=0.008; GLUT-4: r=0.46, P=0.001), but GLUT-1 did not (r=0.21, P=0.147). The tumor size correlated with SUVmax (r=0.5, P<0.001), but GLUT-1, GLUT-3, and GLUT-4 did not (GLUT-1: r=0.006, P=0.681; GLUT-3: r=0.05, P=0.705; GLUT-4: r=-0.17, P=0.217). Both SUVmax and GLUT-4 expressions were statistically significant with ly (+) (SUVmax: P=0.012; GLUT-4: P=0.018), but GLUT-1 and GLUT-3 expressions were not (GLUT-1: P=0.165; GLUT-3: P=0.499). There was no significant difference between other clinicopathological factors and SUVmax or any GLUT expressions.

CONCLUSION

F-FDG uptake in PTC may be determined by GLUT-3 and GLUT-4 expressions and may be related to tumor size and lymph node metastasis of PTC. F-FDG uptake may reflect tumor progression of PTC.

摘要

目的

探讨甲状腺乳头状癌（PTC）患者临床病理因素与氟-18-氟脱氧葡萄糖（F-FDG）摄取之间的关系。

材料与方法

本研究纳入54例患者。术前进行F-FDG正电子发射断层扫描。使用术后组织病理学标本进行葡萄糖转运蛋白（GLUT）免疫组织化学检测。我们研究了最大标准化摄取值（SUVmax）与GLUT-1、GLUT-3和GLUT-4表达之间的关系，以及SUVmax与预后危险因素{肿瘤大小、年龄、性别、甲状腺外侵犯和淋巴结转移[ly(+)]}之间的关系。

结果

GLUT-3和GLUT-4表达与SUVmax显著相关（GLUT-3：r = 0.38，P = 0.008；GLUT-4：r = 0.46，P = 0.001），但GLUT-1与SUVmax无显著相关性（r = 0.21，P = 0.147）。肿瘤大小与SUVmax相关（r = 0.5，P < 0.001），但GLUT-1、GLUT-3和GLUT-4与SUVmax无相关性（GLUT-1：r = 0.006，P = 0.681；GLUT-3：r = 0.05，P = 0.705；GLUT-4：r = -0.17，P = 0.217）。SUVmax和GLUT-4表达与ly(+)均具有统计学意义（SUVmax：P = 0.012；GLUT-4：P = 0.018），但GLUT-1和GLUT-3表达与ly(+)无统计学意义（GLUT-1：P = 0.165；GLUT-3：P = 0.499）。其他临床病理因素与SUVmax或任何GLUT表达之间无显著差异。