Oaks S C, Ng F K, Elwell M R, Groves M G, Lewis G E
Jpn J Med Sci Biol. 1985 Apr;38(2):67-72. doi: 10.7883/yoken1952.38.67.
The pathologic manifestations of the toxic death elicited by the iv injection of mice with Rickettsia tsutsugamushi strain Gilliam were examined by light and scanning electron microscopic techniques to ascertain the cause of death. Light microscopic examinations of hematoxylin and eosin-stained sections of organs suggested the presence of fluid in the lungs; this was confirmed by an increase in the weight of the lungs of moribund mice. Scanning electron microscopy of blood cells demonstrated a marked crenation of erythrocytes from these mice. Death appears to be the result of shock brought on by vascular collapse secondary to plasma leakage.
通过光学显微镜和扫描电子显微镜技术检查了用恙虫病立克次体吉利亚姆株静脉注射小鼠所致中毒死亡的病理表现，以确定死亡原因。对器官苏木精和伊红染色切片的光学显微镜检查表明肺中有液体；濒死小鼠肺重量增加证实了这一点。对血细胞的扫描电子显微镜检查显示这些小鼠的红细胞有明显的皱缩。死亡似乎是血浆渗漏继发血管塌陷所导致的休克的结果。
