胚胎干细胞为 p53 的发育作用提供了新的线索。

Embryonic stem cells shed new light on the developmental roles of p53.

出版信息

Cell Biosci. 2013 Oct 9;3(1):42. doi: 10.1186/2045-3701-3-42.

DOI:10.1186/2045-3701-3-42

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3852614/

Abstract

The viability and subtle developmental defects of p53 knockout mice suggest that p53 does not play major role in development. However, contradictory evidence also exists. This discrepancy mainly results from the lack of molecular and cellular mechanisms and the general fact that p53 activation requires stresses. Recent studies of p53 in mouse and human ES cells and induced pluripotent stem (iPS) cells shed new light on the mechanisms of the developmental roles of p53. This review summarizes these new studies that support the developmental roles of p53, highlights the possible underlying molecular mechanisms, and discusses the potential relationship between the developmental roles and the tumor suppressive function of p53. In summary, the molecular mechanisms underlying the developmental roles of p53 are emerging, and the developmental roles and tumor suppressive function of p53 may be closely related.

摘要

p53 基因敲除小鼠的活力和细微的发育缺陷表明，p53 在发育过程中不起主要作用。然而，也存在矛盾的证据。这种差异主要是由于缺乏分子和细胞机制以及 p53 激活需要应激的普遍事实造成的。最近在小鼠和人类胚胎干细胞和诱导多能干细胞 (iPS 细胞) 中对 p53 的研究为 p53 的发育作用机制提供了新的认识。这篇综述总结了这些支持 p53 发育作用的新研究，强调了可能存在的潜在分子机制，并讨论了 p53 发育作用与其肿瘤抑制功能之间的潜在关系。总之，p53 发育作用的分子机制正在出现，p53 的发育作用和肿瘤抑制功能可能密切相关。