Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, 1070 Arastradero Road #3C03A, Palo Alto, CA, 94304, USA,
Cancer Causes Control. 2014 Jan;25(1):1-10. doi: 10.1007/s10552-013-0280-3. Epub 2013 Oct 31.
The relationship between alcohol consumption and preference of alcohol type with hazard of melanoma (MM) and risk of non-melanoma skin cancer (NMSC) was examined in the Women's Health Initiative (WHI) Observational Study (OS).
A prospective cohort of 59,575 White postmenopausal women in the WHI OS (mean age 63.6) was analyzed. Cox proportional hazards models and logistic regression techniques were used to assess the hazard and risk of physician-adjudicated MM and self-reported NMSC, respectively, after adjusting for potential confounders including measures of sun exposure and skin type.
Over 10.2 mean years of follow-up, 532 MM cases and 9,593 NMSC cases occurred. A significant relationship between amount of alcohol consumed and both MM and NMSC was observed, with those who consume 7+ drinks per week having a higher hazard of MM (HR 1.64 (1.09, 2.49), p global = 0.0013) and higher risk of NMSC (OR 1.23 (1.11, 1.36), p global < 0.0001) compared to non-drinkers. Lifetime alcohol consumption was also positively associated with hazard of MM (p = 0.0011) and risk of NMSC (p < 0.0001). Further, compared to non-drinkers, a preference for either white wine or liquor was associated with an increased hazard of MM (HR 1.52 (1.02, 2.27) for white wine; HR 1.65 (1.07, 2.55) for liquor) and risk of NMSC (OR 1.16 (1.05, 1.28) for white wine; OR 1.26 (1.13, 1.41) for liquor).
Higher current alcohol consumption, higher lifetime alcohol consumption, and a preference for white wine or liquor were associated with increased hazard of MM and risk of NMSC.
在妇女健康倡议观察研究（WHI OS）中，检查了饮酒量和酒精类型偏好与黑色素瘤（MM）危险度和非黑色素瘤皮肤癌（NMSC）风险之间的关系。
分析了 WHI OS 中 59575 名白人绝经后妇女的前瞻性队列（平均年龄 63.6 岁）。使用 Cox 比例风险模型和 logistic 回归技术分别评估了经潜在混杂因素调整（包括日光暴露和皮肤类型测量）后的医师判定 MM 和自我报告 NMSC 的风险。
在 10.2 年的平均随访期间，发生了 532 例 MM 病例和 9593 例 NMSC 病例。观察到饮酒量与 MM 和 NMSC 之间存在显著关系，每周饮酒 7 杯以上的人 MM 的发病风险更高（HR 1.64（1.09，2.49），p 全局=0.0013），NMSC 的风险更高（OR 1.23（1.11，1.36），p 全局<0.0001），与非饮酒者相比。终生饮酒量也与 MM 的发病风险呈正相关（p=0.0011）和 NMSC 的风险呈正相关（p<0.0001）。此外，与非饮酒者相比，更喜欢白葡萄酒或烈性酒与 MM 的发病风险增加相关（白葡萄酒 HR 1.52（1.02，2.27）；烈性酒 HR 1.65（1.07，2.55））和 NMSC 的风险（白葡萄酒 OR 1.16（1.05，1.28）；烈性酒 OR 1.26（1.13，1.41））。
较高的当前饮酒量、较高的终生饮酒量以及对白葡萄酒或烈性酒的偏好与 MM 的发病风险和 NMSC 的风险增加相关。
