Nadeau Joshua, Sulkowski Michael L, Ung Danielle, Wood Jeffrey J, Lewin Adam B, Murphy Tanya K, May Jill Ehrenreich, Storch Eric A
Department of Psychological & Social Foundations, University of South Florida, USA.
Neuropsychiatry (London). 2011 Dec;1(6):567-578. doi: 10.2217/npy.11.62.
Clinically significant anxiety occurs frequently among individuals with autism spectrum disorders (ASDs) and is linked to increased psychosocial, familial, behavioral and academic impairment beyond the core autism symptoms when present. Although efforts are underway to establish empirically supported treatments for anxiety among individuals with ASDs, this remains an emerging research area. This literature review summarizes available information on the efficacy of pharmacological and psychosocial approaches for treating anxiety and repetitive behaviors in children, adolescents and adults with ASDs. Specifically, we evaluate evidence for the use of cognitive-behavioral therapy and selective serotonin-reuptake inhibitors. Evidence is growing in support of using cognitive-behavioral therapy to treat anxiety in youths with ASDs; however, mixed evidence exists for its application in treating repetitive behaviors, as well as the use of selective serotonin-reuptake inhibitors for anxiety in youths with ASDs. We conclude the article with a discussion of the strength of current information and next steps in research.
临床上显著的焦虑症在自闭症谱系障碍（ASD）患者中频繁出现，并且当存在时，它与核心自闭症症状之外的心理社会、家庭、行为和学业损害增加有关。尽管正在努力为患有ASD的个体建立经实证支持的焦虑症治疗方法，但这仍然是一个新兴的研究领域。这篇文献综述总结了关于药物和心理社会方法治疗患有ASD的儿童、青少年和成人焦虑症及重复行为疗效的现有信息。具体而言，我们评估使用认知行为疗法和选择性5-羟色胺再摄取抑制剂的证据。越来越多的证据支持使用认知行为疗法治疗患有ASD的青少年的焦虑症；然而，关于其在治疗重复行为中的应用以及使用选择性5-羟色胺再摄取抑制剂治疗患有ASD的青少年的焦虑症，存在混合证据。我们在文章结尾讨论了当前信息的力度以及研究的下一步方向。
