N-甲基苄胺，人身体中优降宁的一种代谢产物。
N-Methyl-benzylamine, a metabolite of pargyline in man.
作者信息
Pirisino R, Ciottoli G B, Buffoni F, Anselmi B, Curradi C
出版信息
Br J Clin Pharmacol. 1979 Jun;7(6):595-8. doi: 10.1111/j.1365-2125.1979.tb04648.x.
Abstract
- N-methyl-benzylamine was identified in human urine and plasma after the administration of pargyline in man. This metabolite was identified by thin layer chromatography mobility, gas chromatographic retention time and mass spectrum relative to authentic N-methyl-benzylamine. 2. [14C]-N-methyl-benzylamine, together with a small amount of [14C]-benzylamine, was formed in vitro from [14C]-pargyline when this was incubated with human and rat liver microsomes. 3. The urinary excretion rates of pargyline and its metabolite have also been described.
摘要
- 人体服用帕吉林后，在尿液和血浆中发现了N-甲基苄胺。该代谢产物通过薄层色谱迁移率、气相色谱保留时间以及与纯N-甲基苄胺相关的质谱进行鉴定。2. 当[14C]-帕吉林与人及大鼠肝脏微粒体一起孵育时，在体外形成了[14C]-N-甲基苄胺以及少量的[14C]-苄胺。3. 还描述了帕吉林及其代谢产物的尿排泄率。
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