Institut für Mikrobiologie, Universität Düsseldorf, D-4000, Düsseldorf, Germany.
Curr Genet. 1982 Oct;6(1):55-61. doi: 10.1007/BF00397642.
A solo δ sequence flanking the 5' end of the ADHII structural gene, ADR2, can promote a number of DNA rearrangements some of which were investigated in detail. In a selective system haploid mutants were screened in which a solo S sequence flanking ADR2 had been joined to a Ty element. Three different types of events can create such a structure: Reintegration of a Ty sequence at the δ-ADR2 site, inversion of ADR2 and flanking material, and transposition of ADR2 along with 3' flanking material. The involvement of reciprocal or non-reciprocal exchange mechanisms in creating such events are discussed.
ADHII 结构基因 ADR2 侧翼的单个 δ 序列可以促进许多 DNA 重排，其中一些已被详细研究。在一个选择系统中，筛选出了侧翼 ADR2 的单个 S 序列与 Ty 元件相连的单倍体突变体。有三种不同的事件可以产生这种结构：Ty 序列在 δ-ADR2 位点的重新整合、ADR2 和侧翼物质的反转以及 ADR2 及其 3'侧翼物质的转位。讨论了在产生这些事件中涉及的相互或非相互交换机制。
