Scherer S, Davis R W
Science. 1980 Sep 19;209(4463):1380-4. doi: 10.1126/science.6251545.
Yeast transformation can be used to insert new sequence arrangements into a variety of chromosomal locations by homologous recombination. These newly inserted sequences can recombine with similar sequences located on other chromosomes. In these events, information is duplicated without being lost at the site from which it is derived. Similar mechanisms might be utilized by cells to provide new functions during development or differentiation.
酵母转化可用于通过同源重组将新的序列排列插入到各种染色体位置。这些新插入的序列可与位于其他染色体上的相似序列发生重组。在这些事件中，信息被复制，但其来源位点的信息不会丢失。细胞在发育或分化过程中可能利用类似机制来提供新功能。
