二聚酰胺 A 和 B，从内生真菌 Bipolaris sp. MU34 中分离得到的三烯酰胺。

Bipolamides A and B, triene amides isolated from the endophytic fungus Bipolaris sp. MU34.

机构信息

International Center for Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan.

Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, Japan.

出版信息

J Antibiot (Tokyo). 2014 Feb;67(2):167-70. doi: 10.1038/ja.2013.103. Epub 2013 Nov 6.

DOI:10.1038/ja.2013.103

PMID:24192556

Abstract

As a result of the continued screening for new metabolites produced by endophytic fungi from Thai medicinal plants, two new triene fatty acid amides, bipolamides A (1) and B (2), were discovered from the endophytic fungus Bipolaris sp. MU34. The structures of all of the isolated compounds were elucidated on the basis of the spectroscopic data of NMR and MS. An antimicrobial assay revealed that bipolamide B (2) had moderate antifungal activity against Cladosporium cladosporioides FERMS-9, Cladosporium cucumerinum NBRC 6370, Saccharomyces cerevisiae ATCC 9804, Aspergillus niger ATCC 6275 and Rhisopus oryzae ATCC 10404, with Minimum inhibitory concentration (MIC) values of 16, 32, 32, 64 and 64 μg ml(-1), respectively.

摘要

由于对来自泰国药用植物的内生真菌产生的新代谢产物的持续筛选，从内生真菌 Bipolaris sp. MU34 中发现了两种新的三烯脂肪酸酰胺，双极性酰胺 A（1）和 B（2）。根据 NMR 和 MS 的光谱数据，确定了所有分离化合物的结构。抗菌测定表明，双极性酰胺 B（2）对 FERMS-9 点青霉、NBRC 6370 黄瓜炭疽菌、酿酒酵母 ATCC 9804、黑曲霉 ATCC 6275 和米根霉 ATCC 10404 具有中等的抗真菌活性，最小抑菌浓度（MIC）值分别为 16、32、32、64 和 64 μg ml(-1)。