拉基西丁F，一种源自海洋海绵的链霉菌属的新型抗菌环缩肽。
Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp.
作者信息
Kitani Shigeru, Ueguchi Tatsuya, Igarashi Yasuhiro, Leetanasaksakul Kantinan, Thamchaipenet Arinthip, Nihira Takuya
机构信息
International Center for Biotechnology, Osaka University, Osaka, Japan.
Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
出版信息
J Antibiot (Tokyo). 2017 Aug 2. doi: 10.1038/ja.2017.92.
A new cyclic depsipeptide, rakicidin F (1), along with the known compound rakicidin C (2), was isolated from the fermentation broth of the marine sponge-derived actinomycete strain Streptomyces sp. GKU 220. Their structures were elucidated by interpreting the HRFABMS and NMR spectroscopic data. Rakicidin F (1) showed growth inhibitory activity against bacteria.The Journal of Antibiotics advance online publication, 2 August 2017; doi:10.1038/ja.2017.92.
一种新的环缩肽rakicidin F（1），与已知化合物rakicidin C（2）一起，从海洋海绵来源的放线菌菌株链霉菌属GKU 220的发酵液中分离得到。通过解析高分辨快原子轰击质谱（HRFABMS）和核磁共振光谱数据阐明了它们的结构。Rakicidin F（1）对细菌表现出生长抑制活性。《抗生素杂志》在线优先发表，2017年8月2日；doi:10.1038/ja.2017.92 。
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