DKFZ-ZMBH Alliance, Heidelberg, Germany.
EMBO J. 2013 Nov 27;32(23):3009-10. doi: 10.1038/emboj.2013.244. Epub 2013 Nov 5.
EMBO J (2013) 32 23, 3017–3028 ; DOI: 10.1038/emboj.2013.224; published online October 18 2013 Commensal gut bacteria benefit their host in many ways, for instance by aiding digestion and producing vitamins. In a new study in , Jones (2013) report that commensal bacteria can also promote intestinal epithelial renewal in both flies and mice. Interestingly, among commensals this effect is most specific to , the friendly bacteria we use to produce cheese and yogurt. stimulate NADPH oxidase (dNox/Nox1)-dependent ROS production by intestinal enterocytes and thereby activate intestinal stem cells.
共生肠道细菌在许多方面使它们的宿主受益,例如帮助消化和产生维生素。在一项新的研究中,Jones (2013)报告称,共生细菌还可以促进果蝇和小鼠的肠道上皮更新。有趣的是,在共生菌中,这种效应最特定于 ,即我们用于生产奶酪和酸奶的友好细菌。 通过肠道肠细胞激活 NADPH 氧化酶(dNox/Nox1)依赖性 ROS 产生,从而激活肠道干细胞。