Fu Xiu-Jun, Peng Ying-Bo, Hu Yi-Ping, Shi You-Zhen, Yao Min, Zhang Xiong
Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
Department of Burns and Plastic Surgery, No. 3 People's Hospital, Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China ; Department of Burns, The Fourth Hospital Affiliated to Jinan University, Guangzhou 51022, China.
Oxid Med Cell Longev. 2014;2014:282854. doi: 10.1155/2014/282854. Epub 2014 Jan 19.
Reactive oxygen species are mostly viewed to cause oxidative damage to various cells and induce organ dysfunction after ischemia-reperfusion injury. However, they are also considered as crucial molecules for cellular signal transduction in biology. NADPH oxidase, whose only function is reactive oxygen species production, has been extensively investigated in many cell types especially phagocytes. The deficiency of NADPH oxidase extends the process of inflammation and delays tissue repair, which causes chronic granulomatous disease in patients. NADPH oxidase 1, one member of the NADPH oxidase family, is not only constitutively expressed in a variety of tissues, but also induced to increase expression in both mRNA and protein levels under many circumstances. NADPH oxidase 1 and its derived reactive oxygen species are suggested to be able to regulate inflammation reaction, cell proliferation and migration, and extracellular matrix synthesis, which contribute to the processes of tissue injury and repair.
活性氧大多被认为会对各种细胞造成氧化损伤，并在缺血再灌注损伤后诱发器官功能障碍。然而，它们也被视为生物学中细胞信号转导的关键分子。烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶的唯一功能是产生活性氧，它已在许多细胞类型尤其是吞噬细胞中得到广泛研究。NADPH氧化酶的缺乏会延长炎症过程并延迟组织修复，这会导致患者患上慢性肉芽肿病。NADPH氧化酶家族成员之一的NADPH氧化酶1不仅在多种组织中组成性表达，而且在许多情况下还会在mRNA和蛋白质水平上被诱导增加表达。NADPH氧化酶1及其衍生的活性氧被认为能够调节炎症反应、细胞增殖和迁移以及细胞外基质合成，这些都有助于组织损伤和修复过程。
