Larsen Michael Due, Rosholm Jens Ulrik, Hallas Jesper
Clinical Pharmacology, University of Southern Denmark, Odense, Denmark,
Eur J Clin Pharmacol. 2014 Feb;70(2):233-9. doi: 10.1007/s00228-013-1601-x. Epub 2013 Nov 6.
Comprehensive geriatric assessment of hospitalised patients implies optimising patients' medical treatment, and good coordination between hospital and general practice is essential for the quality of the drug treatment. Only a few studies have investigated the continuation of patients' medication from primary care to hospital and back again to primary care.
To describe changes of drug therapy during hospital stay in a geriatric ward and the following acceptance of these changes in primary cares after discharge.
An observational register study following 1,550 geriatric patients' pharmacological treatment longitudinally across hospital stay, by linkage of a primary care prescription database and hospital medical records. The medication regimens for the individual patients were compared at three cross sections: primary care before hospitalisation, during hospital stay and primary care after hospitalisation, analysed according to drug therapy, co-morbidity, functionality and outpatient follow-up.
Patients were using an average of 8.2 drugs before hospital admission, of which an average of 0.9 drugs per patient was discontinued or switched during hospitalisation. An average of 1.7 new drugs per patient was initiated by the hospital physicians. After discharge, 63.9 % of the changes initiated by hospital physicians were continued in primary care. Of new drugs initiated in hospital 42.7 % were accepted in primary care.
A relatively small proportion of drugs was switched or discontinued and the average number of drugs increased during hospital stay. Of these changes, two thirds were accepted in primary care after discharge and less than half of newly initiated drugs were continued in primary.
对住院患者进行全面的老年医学评估意味着优化患者的药物治疗,医院与全科医疗之间的良好协调对于药物治疗质量至关重要。仅有少数研究调查了患者药物治疗从初级保健到医院再回到初级保健的延续情况。
描述老年病房住院期间药物治疗的变化以及出院后初级保健对这些变化的接受情况。
一项观察性登记研究,通过将初级保健处方数据库与医院病历相链接,纵向跟踪1550名老年患者在住院期间的药物治疗情况。在三个时间点比较个体患者的用药方案:住院前的初级保健、住院期间以及住院后的初级保健,并根据药物治疗、合并症、功能状态和门诊随访情况进行分析。
患者入院前平均使用8.2种药物,住院期间平均每位患者有0.9种药物停用或更换。医院医生平均为每位患者新开1.7种药物。出院后,医院医生做出的改变中有63.9%在初级保健中得以延续。在医院新开的药物中,42.7%在初级保健中被接受。
住院期间更换或停用的药物比例相对较小,药物平均数量增加。在这些变化中,三分之二在出院后的初级保健中被接受,新启用药物中不到一半在初级保健中得以延续。