MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.
Diabetologia. 2014 Jan;57(1):73-82. doi: 10.1007/s00125-013-3069-8. Epub 2013 Oct 3.
AIMS/HYPOTHESIS: The aim of our study was to examine the associations between sedentary time (SED-time), time spent in moderate-to-vigorous-intensity physical activity (MVPA), total physical activity energy expenditure (PAEE) and cardiorespiratory fitness with metabolic risk among individuals with recently diagnosed type 2 diabetes.
Individuals participating in the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care (ADDITION)-Plus trial underwent measurement of SED-time, MVPA and PAEE using a combined activity and movement sensor (n = 394), and evaluation of cardiorespiratory fitness (n = 291) and anthropometric and metabolic status. Clustered metabolic risk was calculated by summing standardised values for waist circumference, triacylglycerol, HbA1c, systolic blood pressure and the inverse of HDL-cholesterol. Multivariate linear regression analyses were used to quantify the associations between SED-time, MVPA, PAEE and cardiorespiratory fitness with individual metabolic risk factors and clustered metabolic risk.
Each additional 1 h of SED-time was positively associated with clustered metabolic risk, independently of sleep duration and MVPA (β = 0.16 [95% CI 0.03, 0.29]). After accounting for SED-time, MVPA was associated with systolic blood pressure (β = -2.07 [-4.03, -0.11]) but not with clustered metabolic risk (β = 0.01 [-0.28, 0.30]). PAEE and cardiorespiratory fitness were significantly and independently inversely associated with clustered metabolic risk (β = -0.03 [-0.05, -0.02] and β = -0.06 [-0.10, -0.03], respectively). Associations between SED-time and metabolic risk were generally stronger in the low compared with the high fitness group.
CONCLUSIONS/INTERPRETATION: PAEE was inversely associated with metabolic risk, whereas SED-time was positively associated with metabolic risk. MVPA was not associated with clustered metabolic risk after accounting for SED-time. Encouraging this high-risk group to decrease SED-time, particularly those with low cardiorespiratory fitness, and increase their overall physical activity may have beneficial effects on disease progression and reduction of cardiovascular risk.
ISRCTN99175498.
目的/假设：我们研究的目的是检查久坐时间（SED 时间）、中等到剧烈强度体力活动（MVPA）时间、总体力活动能量消耗（PAEE）与心肺适应性与新诊断 2 型糖尿病个体代谢风险之间的关系。
参加在初级保健中通过屏幕检测糖尿病的强化治疗 Anglo-Danish-Dutch 研究（ADDITION）-Plus 试验的个体使用组合活动和运动传感器（n=394）测量 SED 时间、MVPA 和 PAEE，并评估心肺适应性（n=291）和人体测量学和代谢状态。通过将腰围、三酰甘油、HbA1c、收缩压和高密度脂蛋白胆固醇的倒数标准化值相加来计算聚类代谢风险。使用多元线性回归分析来量化 SED 时间、MVPA、PAEE 和心肺适应性与个体代谢风险因素和聚类代谢风险之间的关系。
SED 时间每增加 1 小时，与聚类代谢风险呈正相关，独立于睡眠时间和 MVPA（β=0.16[95%CI 0.03,0.29]）。在考虑 SED 时间后，MVPA 与收缩压相关（β=-2.07[-4.03，-0.11]），但与聚类代谢风险无关（β=0.01[-0.28，0.30]）。PAEE 和心肺适应性与聚类代谢风险呈显著负相关（β=-0.03[-0.05，-0.02]和β=-0.06[-0.10，-0.03]）。SED 时间与代谢风险之间的关系在低适应性组中比高适应性组更强。
结论/解释：PAEE 与代谢风险呈负相关，而 SED 时间与代谢风险呈正相关。在考虑 SED 时间后，MVPA 与聚类代谢风险无关。鼓励这个高风险组减少 SED 时间，特别是那些心肺适应性低的人，增加他们的整体体力活动可能对疾病进展和降低心血管风险有有益的影响。
ISRCTN99175498。
