Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Curr Opin Cardiol. 2011 Sep;26(5):412-9. doi: 10.1097/HCO.0b013e3283496605.
Prolonged sitting (sedentary behavior) has deleterious cardiovascular and metabolic correlates; however, little is known about the associations of too much sitting with all-cause and cardiovascular mortality risk. In addition to the adverse effects of total sitting time, the manner in which it is accumulated has also been postulated to be important for cardiovascular health.
We describe recent evidence from several research papers published in the last 12-18 months, showing deleterious relationships of sedentary behavior with mortality outcomes. We also explore emerging findings on breaking up sedentary time and its potential beneficial impact on cardiovascular health.
Consistent independent associations have been observed between sitting time/sedentary behaviors and elevated all-cause and cardiovascular disease mortality risk. Generally, these associations have persisted following adjustment for physical activity. Furthermore, total sedentary time (measured objectively via accelerometer) is detrimentally associated with several cardiovascular risk factors, whereas breaking up sedentary time (independent of total sedentary time and moderate-to-vigorous intensity activity) is beneficially associated. This evidence provides further support to the importance of avoiding prolonged, uninterrupted periods of sitting time for cardiovascular health. However, further evidence from intervention trials is required to establish the causal pathways.
久坐（久坐行为）与心血管和代谢不良相关；然而，对于久坐与全因和心血管死亡率风险的关系知之甚少。除了总久坐时间的不良影响外，其积累方式也被认为对心血管健康很重要。
我们描述了过去 12-18 个月内发表的几篇研究论文中的最新证据，这些证据表明久坐行为与死亡率结果之间存在有害关系。我们还探讨了打破久坐时间的新发现及其对心血管健康的潜在有益影响。
久坐时间/久坐行为与全因和心血管疾病死亡率风险升高之间存在一致的独立关联。一般来说，这些关联在调整体力活动后仍然存在。此外，总久坐时间（通过加速度计客观测量）与多种心血管危险因素呈不利相关，而打破久坐时间（与总久坐时间和中等到剧烈强度活动无关）则与有益相关。这一证据进一步支持了避免长时间、不间断的久坐时间对心血管健康的重要性。然而，需要进一步的干预试验证据来确定因果途径。
