Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.
Semin Immunopathol. 2014 Jan;36(1):103-14. doi: 10.1007/s00281-013-0399-z. Epub 2013 Nov 6.
The prevalence of obesity and obesity-related disorders is increasing worldwide. In the last decade, the gut microbiota has emerged as an important factor in the development of obesity and metabolic syndrome, through its interactions with dietary, environmental, and host genetic factors. Various studies have shown that alteration of the gut microbiota, shifting it toward increased energy harvest, is associated with an obese phenotype. However, the molecular mechanisms by which the gut microbiota affects host metabolism are still obscure. In this review, we discuss the complexity of the gut microbiota and its relationship to obesity and obesity-related diseases. Furthermore, we discuss the anti-obesity potential of probiotics and prebiotics.
肥胖症和肥胖相关疾病的患病率在全球范围内不断上升。在过去的十年中，肠道微生物群已成为肥胖症和代谢综合征发展的一个重要因素，通过与饮食、环境和宿主遗传因素的相互作用。各种研究表明，肠道微生物群的改变，使其朝着增加能量收获的方向发展，与肥胖表型有关。然而，肠道微生物群影响宿主代谢的分子机制仍不清楚。在这篇综述中，我们讨论了肠道微生物群的复杂性及其与肥胖症和肥胖相关疾病的关系。此外，我们还讨论了益生菌和益生元的抗肥胖潜力。
