Cheng Shidan, Wang Liying, Wang Lei, Wang Zhengting
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.
Department of Gastroenterology, Shangyu People's Hospital Shaoxing 312000, Zhejiang Province, China.
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1911-9. eCollection 2015.
The association between the X-ray repair cross-complementing group 3 (XRCC3) gene Thr241Met polymorphism (rs861539) and gastric cancer has been widely evaluated, but a definitive answer is so far lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. Although our case-control association study and the following meta analysis involving 6,520 subjects indicated null association of XRCC3 gene rs861539 polymorphism between gastric cancer patients and controls under both allelic (odds ratio (OR) = 1.02; 95% confidence interval (CI): 0.91-1.14; P = 0.739) and dominant (OR = 0.97; 95% CI: 0.78-1.21; P = 0.803) models. Stratified analysis by ethnicity demonstrated a significant association in Asians. We conclude that the XRCC3 gene rs861539 polymorphism was associated with the risk for gastric cancer in Asian populations.
X射线修复交叉互补基因3（XRCC3）基因Thr241Met多态性（rs861539）与胃癌之间的关联已得到广泛评估，但迄今为止仍缺乏明确答案。我们首先进行了一项病例对照研究，以评估在一大群中国汉族人群中的这种关联，然后进行了一项荟萃分析以进一步解决这个问题。尽管我们的病例对照关联研究以及随后涉及6520名受试者的荟萃分析表明，在等位基因（优势比（OR）=1.02；95%置信区间（CI）：0.91-1.14；P=0.739）和显性（OR=0.97；95%CI：0.78-1.21；P=0.803）模型下，胃癌患者与对照组之间XRCC3基因rs861539多态性无关联。按种族进行的分层分析表明在亚洲人群中有显著关联。我们得出结论，XRCC3基因rs861539多态性与亚洲人群患胃癌的风险相关。
